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October 11, 2025Journal of Cellular Physiology

Bidirectional Regulatory Mechanisms of Disulfidptosis Govern Precision Targeting in Degenerative Bone Diseases and Osteosarcoma

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Authors

XZXiaoming ZhaoSWShaobo WuXSXiaochen Su

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Overview

Review explores disulfidptosis's role in degenerative conditions and bone tumors, suggesting immunometabolic interventions.

Key Points

  • Disulfidptosis significantly influences the development of osteosarcoma and degenerative bone diseases.
  • Key regulatory mechanisms involve the SLC7A11 molecule, which plays a crucial role in cystine metabolism.
  • The analysis presents potential precision strategies combining disulfidptosis-targeted interventions with immunotherapy.
  • Understanding disulfidptosis may lead to novel approaches in managing orthopedic diseases and related tumors.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1c1ba7d64b6fc13232bhttps://doi.org/10.1002/jcp.70100
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation2026
  2. 2Disulfidptosis Nanoinducer Interrupts Tumor Metabolic Privilege to Boost Sustained Immunotherapy.2025 · 29 citations
  3. 3A disulfidptosis‐related gene signature predicts prognosis and immune‐metabolic landscape in multiple myeloma2025
  4. 4A novel disulfidptosis-related mRNA signature predicts prognosis and therapeutic response in lung squamous cell carcinoma2025 · 1 citations
  5. 5Molecular mechanisms and potential implications of ferroptosis, cuproptosis, and disulfidptosis in septic lung injury2025