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July 12, 2026Cell Death and DifferentiationOpen Access

Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation

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Authors

YYYuelong YanLZLi ZhuangBGBoyi Gan

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Overview

Exploration of disulfidptosis and its role in cellular response to nutrient deprivation highlights key regulatory pathways.

Key Points

  • Investigate whether disulfidptosis is a direct result of glucose deprivation or regulated by stress responses.
  • Explored the biochemical mechanisms underlying disulfidptosis.
  • Analyzed the role of SLC7A11 in nutrient deprivation-related cell death.
  • Assessed the impact of disulfidptosis on actin cytoskeleton integrity.
  • Disulfidptosis characterized by cytoskeleton collapse due to disulfide stress.
  • High SLC7A11 expression leads to increased cystine uptake and NADPH depletion.
  • Disulfidptosis represents a distinct metabolic cell death pathway from apoptosis and necroptosis.

Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/6a532e014f7abc118adeca43https://doi.org/10.1038/s41418-026-01817-3
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