Cardiac fibroblast-mediated ECM remodeling regulates maturation in an in vitro 3D engineered cardiac tissue

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Enhanced maturation results from fibroblast-driven collagen deposition and tissue contraction, indicating their crucial role.
Functional and structural maturation of engineered cardiac tissue improved with fibroblast activity, as shown by morphology and mRNA analysis.
Assessment using a 3D in vitro model revealed that inhibition of ECM remodeling impaired maturation outcomes.
Excess collagen accumulation limits contractile efficiency, suggesting a delicate balance is necessary for optimal heart tissue function.

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Observational analysis finds ECM remodeling by cardiac fibroblasts enhances maturation in 3D models, suggesting its role in cardiac development.

Jang et al. (2025) studied this question.

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Observational analysis finds ECM remodeling by cardiac fibroblasts enhances maturation in 3D models, suggesting its role in cardiac development.