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October 10, 2025Jurnal Farmasi Sains dan PraktisOpen Access

Analysis and Validation of Detection Method for Ethylene and Diethylene Glycol Contaminants in Syrup Using GCMS (Gas Chromatography-Mass Spectrometer)

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Authors

SSSupandi SupandiMMMabrurotul MustafidahSYSiti Yaenap

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Overview

GC-MS reveals EG and DEG contamination in children's syrup drugs, indicating a need for stringent safety measures.

Key Points

  • Detection of ethylene glycol and diethylene glycol contamination was confirmed in syrup samples with concentrations below 0.1%.
  • Validation tests showed high accuracy, with recovery rates between 98% and 101% for the GC-MS method used.
  • The limit of detection for ethylene glycol was 0.26 ng/mg, while diethylene glycol was 0.51 ng/mg.
  • Ensuring reliable detection methods is critical for pharmaceutical safety, highlighting potential public health risks.

Cite This Study

Supandi et al. (2025) studied this question.

synapsesocial.com/papers/68e861a57ef2f04ca37e470bhttps://doi.org/10.31603/pharmacy.v11i2.11180
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1B-277 Validation of an Enzymatic Method for Quantification of Ethylene Glycol in Human Serum2025
  2. 2B-325 Evaluation of Ethylene Glycol Stability in Blood and Serum: Impact of Pre-Analytical Conditions and Performance Comparison of an Automated Enzymatic Assay vs. Gas Chromatography-Mass Spectrometry in Clinical Toxicology2025
  3. 3B-310 Evaluation of a Quantitative Enzymatic Ethylene Glycol Method on the Beckman AU5800 Platform2025
  4. 4Development and Validation of a Headspace Gas Chromatography–Mass Spectrometry Method for the Identification and Quantification of Glycol Ethers in Cosmetic Cream Formulations2025
  5. 5B-314 Automated Enzymatic Assay for Measuring Ethylene Glycol2025