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October 10, 2025Open Access

Antidiabetic Properties of Polyalthia longifolia: A Comprehensive In Vitro Study of Leaf and Stem Extracts

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Authors

GFGuglielmina FroldiMSMarguérite Kamdem SimoLTLuciana Tomasi

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Overview

In vitro analysis reveals significant antihyperglycemic and antiglycation properties of polyalthia longifolia extracts, suggesting potential medicinal uses.

Key Points

  • Ethanol and methanol extracts from polyalthia longifolia leaves demonstrate significant antidiabetic activity, enhancing therapeutic potential.
  • The study revealed impactful effects on hyperglycemia, with extracts showcasing strong antihyperglycemic and antiglycation properties.
  • Phytochemical analysis identified bioactive compounds, including phenolic compounds and flavonoids like baicalein, contributing to the findings.
  • MTT assays indicated slight cytotoxicity on HT-29 human cell line, highlighting the need for careful evaluation in therapeutic applications.

Cite This Study

Froldi et al. (2025) studied this question.

synapsesocial.com/papers/68e861907ef2f04ca37e3fc6https://doi.org/10.20944/preprints202509.2576.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phytochemistry, Traditional Uses, and Pharmacological Properties of Polyalthia longifolia2025
  2. 2Phytochemical Analysis and Biological Activity of the Leaf Extracts of Polyalthia longifolia (Masquerade Tree)2025
  3. 3Isolation and Characterization of Methanolic Stem Bark Extracts of <i>Polyalthia longifolia</i> and Root Extract of <i>Annona senegalensis</i> Plants2025
  4. 4Effects of Selected Medicinal Plants on Enzymatic Targets Related to Diabetes Mellitus and Obesity2025 · 1 citations
  5. 5Bifunctional Systems of Amelanchier alnifolia Leaves Extract-Oligosacharides with Prebiotic and Antidiabetic Benefits2025 · 3 citations