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October 10, 2025Journal of Diabetes ResearchOpen Access

Differential Effects of Aerobic, Resistance, and Combined Trainings on First‐ and Second‐Phase Insulin Secretion and Glucose Effectiveness in Type 2 Diabetes: A Randomized Controlled Trial

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Authors

EPElaheh PiralaiyARAlireza RashidpourBIBadrkhan Rashwan Ismael

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Overview

Randomized controlled trial shows combined training improves insulin secretion and glucose effectiveness in type 2 diabetes patients, indicating multimodal approaches may be advantageous.

Key Points

  • Combined training improved first-phase insulin secretion by 53.4%, second-phase insulin secretion by 38.9%, and glucose effectiveness by 12.8%.
  • Aerobic training enhanced first-phase insulin secretion by 32.6% and second-phase by 21.7%, while resistance training improved first-phase by 28.5% and glucose effectiveness by 10.7%.
  • Randomized controlled trial with 45 male patients lasted 12 weeks, assessing effects on biphasic insulin secretion and glucose effectiveness.
  • Findings support the role of multimodal exercise in boosting β-cell function and glycemic control in type 2 diabetes patients.

Cite This Study

Piralaiy et al. (2025) studied this question.

synapsesocial.com/papers/68e861857ef2f04ca37e3a3ahttps://doi.org/10.1155/jdr/9922344
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of nine different exercise interventions on insulin sensitivity in diabetic patients: a systematic review and mesh meta-analysis2025
  2. 2Comparative effectiveness of different exercise modality on glycaemic control and lipid profile for prediabetes: systematic review and network meta-analysis2025
  3. 3Effects of different types of exercise interventions on metabolic and cardiorespiratory fitness in children and adolescents with type 1 diabetes mellitus:a systematic review and network meta-analysis2025
  4. 4<b>Combined Effects of Balance Training with Moderate-Intensity Aerobic Versus Resistance Training on Glycemic Control, Cardiorespiratory Fitness, and Quality of Life in Type 2 Diabetes Mellitus Patients</b>2025
  5. 5Exercise modalities and dosages on glycated haemoglobin and exerkines in type 2 diabetes: a systematic review with pairwise, network, and dose-response meta-analyses2026