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October 9, 2025Circulation Research

Abstract Thu153: Divergent Sex-Specific Effects of Estrogen on Cardiac Function: The Intersection of Adora2b Signaling and IL-6 Regulated Ferroptosis

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Authors

SASyed Anees AhmedDebre Berhan UniversityAAAbdel A. Abdel‐RahmanEast Carolina University

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Implication

Observational analysis shows divergent estrogen impacts on cardiac function in males and females, indicating IL-6's role in outcomes.

Key Points

  • Estrogen treatment improved cardiac function in ovariectomized females, while impairing it in males.
  • E2 reduced blood pressure in females but did not alter it in males, highlighting gender differences.
  • Increased IL-6 and ferroptosis were observed in males, suggesting negative cardiac impacts from estrogen.
  • Divergent estrogen effects on cardiac health emphasize the need for sex-specific therapeutic strategies.

Cite This Study

Ahmed et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877df6https://doi.org/10.1161/res.137.suppl_1.thu153
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex hormone-specific regulation of ferroptosis in vascular cells in atherosclerosis: molecular mechanisms and targeted strategies2025 · 4 citations
  2. 2Abstract Thu156: Impacts of Estradiol and Progesterone On Cardiomyocyte Cell Dynamics and Mitochondrial Respiration2025
  3. 3Multiple oestradiol functions inhibit ferroptosis and acute kidney injury2025 · 76 citations
  4. 4Abstract Thu162: Sex Chromosomes and Sex Hormones Independently Contribute to Heart Failure with Preserved Ejection Fraction2025
  5. 5Abstract Thu157: Deciphering the drivers of cardiac sex differences in the ObscurinΔIg58/59 mouse model2025