Abstract Thu157: Deciphering the drivers of cardiac sex differences in the ObscurinΔIg58/59 mouse model

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This study explores cardiac remodeling and arrhythmias in ObscurinΔIg58/59 mice, highlighting the roles of estrogens and phytoestrogens.

Depletion of estrogens induced remodeling of the left ventricle in ΔIg58/59 females, but not arrhythmias.
Females in the ObscnΔIg58/59 model remained phenotypically normal despite cardiac changes in males.
Ovarian hormone removal and diet alterations were key to understanding cardiac health in female mice.
Current studies are examining how letrozole and dihydrotestosterone affect heart structure in ΔIg58/59 females.

Brong et al. (2025) studied this question.

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