October 9, 2025Circulation Research

Abstract Thu148: PDGFRβ Expression Marks a Multipotent Cardiac Fibroblast Population that Drives Fibrosis and Inflammation in Heart Failure

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Activated PDGFRβ in cardiac fibroblasts promotes fibrosis and inflammation, leading to heart dysfunction.
Echocardiographic analysis revealed elevated global longitudinal strain in Tg mice but no significant cardiac function changes.
Transgenic mice with PDGFRβ activation in cardiac fibroblasts showed increased myocardial fibrosis and inflammation.
Modulating PDGFRβ expression could provide new therapeutic approaches for managing chronic heart failure.

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Implication

Research demonstrates that activated PDGFRβ in cardiac fibroblasts drives fibrosis and inflammation in heart failure, suggesting potential therapeutic strategies.

Cite This Study

Hamid et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fc16 https://doi.org/10.1161/res.137.suppl_1.thu148

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Implication

Research demonstrates that activated PDGFRβ in cardiac fibroblasts drives fibrosis and inflammation in heart failure, suggesting potential therapeutic strategies.

Abstract Thu148: PDGFRβ Expression Marks a Multipotent Cardiac Fibroblast Population that Drives Fibrosis and Inflammation in Heart Failure

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Discussion

Implication

Cite This Study

Abstract Thu148: PDGFRβ Expression Marks a Multipotent Cardiac Fibroblast Population that Drives Fibrosis and Inflammation in Heart Failure

Key Points

Discussion

Implication

Cite This Study

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