Abstract Wed025: Cardiomyocyte-GSK-3β exerts a critical break on fibro-inflammatory mechanisms to maintain cardiac homeostasis.

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CM-GSK-3β knockout leads to severe systolic dysfunction and dilative remodeling in mice.
Echocardiographic assessment revealed increased heart weight and signs of cardiac hypertrophy in knockout mice.
Flow cytometry confirmed a significant rise in immune and fibroblast cell activity in the absence of CM-GSK-3β.
Findings suggest that CM-GSK-3β is essential for regulating inflammation and maintaining cardiac health.

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Analysis shows CM-GSK-3β influences cardiac remodeling and inflammation in mutant hearts, highlighting its role in cardiac homeostasis.

Bhati et al. (2025) studied this question.

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