October 9, 2025Circulation Research

Abstract Thu022: Mitochondrial Dysfunction and Metabolic Therapies for Heart Failure Derived From the Pediatric Heart

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Authors

FLFatemeh Mirshafiei LangariHospital for Sick Children TLTim LeeHospital for Sick Children KHKaley HogarthUniversity of Toronto

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Implication

Observational analysis shows metabolic therapies improve heart function in cardiac progenitor cells, suggesting pediatric heart benefits could aid adult heart failure.

Key Points

Secretome treatment significantly improved cardiac contractility and mitochondrial function in cardiomyocytes.
Mass spectrometry identified over 400 proteins with ENO1 as a key metabolic regulator linked to improved heart function.
Injecting secretome into rats post-LAD ligation enhanced cardiac performance, indicating potential therapeutic pathways.
Transfer of pediatric heart regulatory mechanisms may offer new approaches for adult heart failure treatments.

Cite This Study

Langari et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fc12 https://doi.org/10.1161/res.137.suppl_1.thu022

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Implication

Observational analysis shows metabolic therapies improve heart function in cardiac progenitor cells, suggesting pediatric heart benefits could aid adult heart failure.

Abstract Thu022: Mitochondrial Dysfunction and Metabolic Therapies for Heart Failure Derived From the Pediatric Heart

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract Thu022: Mitochondrial Dysfunction and Metabolic Therapies for Heart Failure Derived From the Pediatric Heart

Discussion

Member takes

Implication

Key Points

Cite This Study

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