Abstract Wed002: Deregulation of RNA Pol III-dependent genes in myocardial hypertrophy

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Discussion

Deregulation of RNA Pol III-dependent genes influences myocardial hypertrophy, suggesting new therapeutic targets.

Increased expression of RNA Pol III-dependent genes may be critical in myocardial hypertrophy.
Brf1, a transcription factor, is significantly elevated in hypertrophic myocardial tissue.
Over 50% of HCM patients lack mutations in typical sarcomere genes, pointing to diverse mechanisms.
Models of myocardial hypertrophy showed significant RNA Pol III gene transcription increase.

Zheng et al. (2025) studied this question.

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