Abstract Wed015: Stress Induced RNA Decay In Cardiac Hypertrophy

View Full Paper

Ask AI

Bookmark

Authors

Discussion

This study demonstrates the impact of Upf1-mediated mRNA degradation on cardiac hypertrophy and inflammation.

Altered mRNA stability was found in stressed myocytes, suggesting a new area of focus in cardiac hypertrophy.
Loss of Upf1 expression led to significant cardiac hypertrophy, highlighting its potential role in cellular homeostasis.
Using BRIC-Seq and other techniques, we uncovered the regulatory mechanisms of mRNA stability linked with Upf1.
Targeting Upf1-RBFox1 interactions may open new therapeutic avenues for managing cardiac diseases.

Song et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark