Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 9, 2025Circulation Research

Abstract Wed180: Three-dimensional whole-heart immunopathogenic profiling of immune foci during acute mouse viral myocarditis

View Full Paper
Ask AI
Bookmark
Share

Authors

ADAbdel Rahman DaoudJohns Hopkins UniversityHKHannah KalinoskiMTMonica Vladut TalorJohns Hopkins University

Discussion

Loading...

Member takes

Implication

This research reveals spatial heterogeneity of immune foci in myocarditis, highlighting distinct T cell and macrophage niches.

Key Points

  • 3D reconstruction identified distinct immune foci during myocarditis, demonstrating T cell and macrophage specialization.
  • Quantification of immune foci revealed T cell and macrophage localization linked to fibrosis, with statistical significance (p<0.05).
  • Flow cytometry and IHC validated spatial differences in immune cell populations in myocarditis and human DCM.
  • Understanding spatial heterogeneity in immune foci could advance insights into fibrosis mechanisms in myocarditis.

Cite This Study

Daoud et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fb4ahttps://doi.org/10.1161/res.137.suppl_1.wed180
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract Fri033: Tissue transcriptomics of endomyocardial biopsies in human myocarditis reveals widespread molecular perturbations independent of leukocyte-rich foci2025
  2. 2Tissue transcriptomics of endomyocardial biopsies reveals widespread molecular perturbations independent of leukocyte-rich foci in human myocarditis2025
  3. 3Single-Cell Multi-Omics Identifies Specialized Cytotoxic and Migratory CD8 + Effector T Cells in Acute Myocarditis2025 · 14 citations
  4. 4Dissecting myocardial and systemic drivers of cardiac dysfunction in the murine CVB3 myocarditis model using microRNA-guided viral detargeting2026 · 1 citations
  5. 5Cardiac MRI Monitoring of Myocardial Tissue Changes in a Myocarditis Mouse Model with Histologic Validation2026