August 5, 2025Open Access

Tissue transcriptomics of endomyocardial biopsies reveals widespread molecular perturbations independent of leukocyte-rich foci in human myocarditis

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Discussion

Spatial transcriptomic profiling reveals widespread gene expression changes in myocarditis, highlighting immune activation mechanisms.

Myocarditis shows extensive transcriptional dysregulation, revealing insights beyond immune cell foci.
Differential gene expression analysis identified key pathways activated in cardiomyocytes during myocarditis.
Two complementary transcriptomic profiling platforms were used to analyze endomyocardial biopsy specimens.
Results suggest new avenues for diagnosing and targeting myocarditis therapeutically.

Cohen et al. (2025) studied this question.

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