October 9, 2025Circulation Research

Abstract Thu136: Gfpt2 Modulates the Cardiac Fibroblast to Myofibroblast Transition Through Metabolic Reprogramming

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Gfpt2 modulates cardiac fibroblast activation, shifting them to a more myofibroblast-like state after ischemic injury.
After Gfpt2 knockdown, significant gene expression changes and extracellular matrix pathways were upregulated.
Analysis revealed overlapping pathways between Gfpt2 knockdown and cardiac fibroblast activation during ischemic responses.
Glutathione metabolism emerged as a crucial pathway linked to CF activation and ischemic injury responses.

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Implication

This analysis investigates Gfpt2's role in cardiac fibroblast transformation to myofibroblasts, suggesting metabolic pathways influence cellular activation.

Cite This Study

Takasugi et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fb28 https://doi.org/10.1161/res.137.suppl_1.thu136

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Implication

This analysis investigates Gfpt2's role in cardiac fibroblast transformation to myofibroblasts, suggesting metabolic pathways influence cellular activation.

Abstract Thu136: Gfpt2 Modulates the Cardiac Fibroblast to Myofibroblast Transition Through Metabolic Reprogramming

Key Points

Discussion

Implication

Cite This Study

Abstract Thu136: Gfpt2 Modulates the Cardiac Fibroblast to Myofibroblast Transition Through Metabolic Reprogramming

Key Points

Discussion

Implication

Cite This Study

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