October 9, 2025Open Access

Alzheimer's disease causes bone marrow myelopoiesis dysfunction

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Myelopoiesis dysfunction correlates with the progression of Alzheimer's disease, affecting immune response and cognitive decline.
Impaired monocyte development and differentiation were observed in both Alzheimer's patients and the 5xFAD mouse model.
Blocking type I interferon signaling can restore normal myelopoiesis function and improve cognitive outcomes in affected models.
These findings prompt a reevaluation of how neurodegenerative diseases relate to bone marrow function, emphasizing broader systemic effects.

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This research uncovers myelopoiesis dysfunction in Alzheimer's patients and mice, suggesting neurodegenerative diseases affect bone marrow roles.

Abellanas et al. (2025) studied this question.

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This research uncovers myelopoiesis dysfunction in Alzheimer's patients and mice, suggesting neurodegenerative diseases affect bone marrow roles.