September 20, 2025The Journals of Gerontology Series A

Infusion of peripheral blood mononuclear cell alleviates amyloid accumulation and cognitive deficits in Alzheimer's disease

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Infusion of PBMCs led to reduced amyloid plaques and improved cognitive function in AD mice, indicating potential therapeutic benefits.
Analysis identified differentially expressed genes related to apoptosis and synaptic organization, highlighting key pathways in Alzheimer's pathology.
Methods included single-cell RNA sequencing and injection of PBMCs in age-matched AD mouse models to assess cognitive impact.
Findings suggest JUN expression in PBMCs may be a valuable biomarker for diagnosing Alzheimer's disease in patients.

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Implication

Infusion of peripheral blood mononuclear cells significantly improves cognitive function in Alzheimer's patients, suggesting a new therapeutic approach.

Cite This Study

Xue et al. (2025) studied this question.

synapsesocial.com/papers/68d43809713b0b5dfea78495 https://doi.org/10.1093/gerona/glaf193

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Implication

Infusion of peripheral blood mononuclear cells significantly improves cognitive function in Alzheimer's patients, suggesting a new therapeutic approach.

Infusion of peripheral blood mononuclear cell alleviates amyloid accumulation and cognitive deficits in Alzheimer's disease

Key Points

Discussion

Implication

Cite This Study

Infusion of peripheral blood mononuclear cell alleviates amyloid accumulation and cognitive deficits in Alzheimer's disease

Key Points

Discussion

Implication

Cite This Study

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Also Consider