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October 8, 2025Scientific ReportsOpen Access

The role of vitamin C in melanoma cell death via activation of cytochrome C and TNF-α protein expression

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Authors

ESEva Krishna SutedjaTATiara Rachmaputeri AriantoGEGhabrina Saraswati Elgianda

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Overview

This study demonstrates enhanced apoptosis in melanoma cells, highlighting vitamin C's role in cytochrome c and TNF-α expression.

Key Points

  • Vitamin C significantly increases cytochrome c and TNF-α expression in melanoma cells, inducing apoptosis.
  • Caspase-3 expression showed meaningful increments at vitamin C concentrations of 3,000 µM and 5,000 µM.
  • Exposure for 12 hours resulted in observable signs of cell death, indicating the effectiveness of vitamin C treatment.
  • Gene expression analysis revealed that vitamin C initiates multiple apoptotic pathways in B16-F10 melanoma cells.

Cite This Study

Sutedja et al. (2025) studied this question.

synapsesocial.com/papers/68e6860af44b9035634c2001https://doi.org/10.1038/s41598-025-18372-5
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