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October 8, 2025BMC AnesthesiologyOpen Access

Remimazolam vs. dexmedetomidine for postoperative sedation in oral tumor patients undergoing free flap reconstruction: a randomized controlled pilot trial

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Authors

YLYun LiuLWLi‐Kuan WangGXGuo‐Li Xiong

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Overview

Randomized controlled trial indicates remimazolam and dexmedetomidine have comparable efficacy, suggesting remimazolam may enhance hemodynamic stability.

Key Points

  • Emergence agitation incidence was similar between remimazolam and dexmedetomidine at 27.6% vs. 25.0%, p > 0.999.
  • Remimazolam notably reduced colloid use in the PACU, with 3.4% versus 32.1%, leading to a p-value of 0.005.
  • This randomized double-blind trial involved 60 patients undergoing microvascular reconstruction, with final analysis on 57 patients.
  • Findings underscore remimazolam's potential as a favorable option for postoperative sedation, given its rapid offset.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68e6679587ecc93a24d1742ehttps://doi.org/10.1186/s12871-025-03346-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comparison of Single Dose Remimazolam With Dexmedetomidine for the Prevention of Emergence Delirium in Children Undergoing Tonsillectomy and Adenoidectomy Surgery Under Sevoflurane Anesthesia: A Randomized Clinical Trial.2025
  2. 2Efficacy and safety of remimazolam for induction and maintenance of general anesthesia in day surgery: a randomized controlled non-inferiority clinical trial2025
  3. 3Evaluation of the Safety and Efficacy of Remimazolam Combined With Remifentanil for Sedation in Adult Dental Anxiety Patients Undergoing Mandibular Impacted Third Molar Extraction: A Single-Center, Retrospective Cohort Analysis2025
  4. 4The efficacy and safety of remimazolam for the management of emergence agitation: a randomized, double-blind, placebo-controlled study2025
  5. 5Remimazolam Enables Faster Sedation Induction and Recovery Compared With Midazolam in Diagnostic Upper Gastrointestinal Endoscopy: A Multicenter Randomized Controlled Trial2025