Pilot Study of Daily Exemestane in Women with Endometrial Intraepithelial Neoplasia or Low Grade Endometrial Cancer

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Pilot study evaluates exemestane’s anti-proliferative effects in women with endometrial neoplasia, suggesting its potential for cancer prevention.

Exemestane reduced Ki-67 scores by a median of 20.4%, indicating anti-proliferative effects.
The study included 40 participants with diagnoses like EIN and low-grade endometrial cancer.
Significant decreases in tissue ER and PR expression were observed with exemestane treatment.
Safety and adverse effects were monitored alongside hormonal measurements throughout the study.

Erickson et al. (2025) studied this question.

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Pilot study evaluates exemestane’s anti-proliferative effects in women with endometrial neoplasia, suggesting its potential for cancer prevention.