October 3, 2025Frontiers in ImmunologyOpen Access

Emerging macrophage-based therapies for cancer: a review of preclinical and clinical advances

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Macrophage-based therapies show promise as powerful allies in cancer treatment, enhancing efficacy of immunotherapies.
Innovative strategies include checkpoint blockade and macrophage-drug conjugates, as evidenced by ongoing clinical trials.
The review discusses RNA-based reprogramming and macrophage-derived extracellular vesicles as new frontiers in cancer therapy.
These approaches suggest a paradigm shift in utilizing macrophages not only as targets but also as therapeutic delivery vehicles.

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This review highlights emerging macrophage-based immunotherapies and their integration into clinical trials, suggesting innovative strategies for targeting tumors.

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Brancewicz et al. (2025) studied this question.

synapsesocial.com/papers/68e040eda99c246f578b3477 https://doi.org/10.3389/fimmu.2025.1679271

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Implication

This review highlights emerging macrophage-based immunotherapies and their integration into clinical trials, suggesting innovative strategies for targeting tumors.

Emerging macrophage-based therapies for cancer: a review of preclinical and clinical advances

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Discussion

Implication

Cite This Study

Emerging macrophage-based therapies for cancer: a review of preclinical and clinical advances

Key Points

Discussion

Implication

Cite This Study

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