October 3, 2025Clinical ChemistryOpen Access

A-069 Comparison of Three Hemoglobin A1c Methodologies in Variant and Non-Variant Samples

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HPLC, CE, and IA methods effectively measured HbA1c in non-variant samples, showing high accuracy.
Among 317 non-variant samples, 92.4% of HPLC/CE results fell within the acceptable range of +/-0.3%.
Variant testing revealed unique capabilities, where IA outperformed in producing numeric results even for absent HbA.
Understanding the limitations and strengths of each method is crucial for effective diabetes management.

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Observational study compares HbA1c results from three methodologies in variant and non-variant samples, indicating varying accuracy.

Rosemark et al. (2025) studied this question.

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