Analytical study compares HbA1c accuracy in diabetes using enzymatic method and capillary electrophoresis under lipemia, suggesting increased reliability of CE.
Key Points
Capillary electrophoresis proves to be more reliable than the enzymatic method for measuring HbA1c under severe lipemia.
Significant false elevation in HbA1c was observed with the enzymatic method at high lipemia (P < 0.01).
Saline washing did not mitigate lipemic interference in the enzymatic method, leading to further inaccuracies.
Capillary electrophoresis maintained stable results, indicating its higher resistance to matrix interferences.