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October 3, 2025Open Access

Global dynamics of antibiotic resistance: a modeling study of the spread of endemic and emerging resistance in E. coli

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Authors

EREve RahbéEVEugenio ValdanoDSDavid R. Smith

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Overview

Mechanistic modeling reveals transmission dynamics of E. coli resistance in different regions, suggesting key interventions.

Key Points

  • Emerging resistant clones of E. coli can be controlled by improving surveillance and data collection.
  • The study indicates transmission rates vary significantly, with Spain averaging 7.05x10-3 day-1 compared to 16.21x10-3 day-1 in Thailand.
  • Analyzing antibiotic prescriptions and human mobility highlights the drivers of antibiotic resistance spread, especially across borders.
  • The findings underline that reducing transmission and selection pressure are vital to mitigate antibiotic resistance on a global scale.

Cite This Study

Rahbé et al. (2025) studied this question.

synapsesocial.com/papers/68e02f46f0e39f13e7fa2ce7https://doi.org/10.1101/2025.09.25.25335519
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mapping the trajectory of antibiotic resistance from ESBL-producing to carbapenem-resistant Enterobacteriaceae: A bibliometric study from 2000 to 20252025
  2. 2Phylogenetic context of antibiotic resistance provides insights into the dynamics of resistance emergence and spread2025
  3. 3GLOBAL PATTERNS OF ANTIBIOTIC RESISTANCE DEVELOPMENT IN COMMON BACTERIAL INFECTIONS AND THEIR IMPLICATIONS FOR TREATMENT STRATEGIES: A SYSTEMATIC REVIEW2025
  4. 4Insights Into Global Antimicrobial Resistance Dynamics Through the Sequencing of Enteric Bacteria From US International Travelers2025
  5. 5Ecological Kinetics and Evolutionary Dynamics of Antibiotic Resistance in Complex Environments2025