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October 3, 2025ChemistrySelectOpen Access

Natural Products from Mexican Medicinal Plants as Promising Trypanocidal Drugs

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Authors

KRKarla Daniela Rodríguez‐HernándezEJElia Guadalupe Jaimes‐CastelánRRRicardo Reyes‐Chilpa

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Overview

This review assesses anti-T. cruzi compounds in medicinal plants, suggesting new trypanocidal drugs to combat Chagas disease.

Key Points

  • Secondary metabolites from Mexican plants show potential as new trypanocidal drugs against Chagas disease.
  • Current treatments like nifurtimox and benznidazole have low efficacy and can cause toxicity, highlighting the need for better options.
  • The review focuses on literature from 2012 to 2024, identifying compounds with activity against stages of Trypanosoma cruzi.
  • In vivo trials and pharmacokinetic studies are essential for advancing these natural products into effective therapies.

Cite This Study

Rodríguez‐Hernández et al. (2025) studied this question.

synapsesocial.com/papers/68e02f40f0e39f13e7fa2a44https://doi.org/10.1002/slct.202504830
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antiparasitic Effect of Polyphenols and Terpenes from Natural Products Against Trypanosoma cruzi and Leishmania mexicana2025 · 9 citations
  2. 2Combination Therapy in Experimental Chagas Disease: A Review2025
  3. 3Buddleja globosa Leaf Methanolic Extract Acts Against Trypanosoma cruzi Parasites by Inducing Mitochondrial Inner Membrane Hyperpolarization2025
  4. 4In Vitro Evaluation of p-Toluenesulfonyl Hydrazones as Anti-Trypanosoma cruzi and Leishmanicidal Agents2025
  5. 5Antiparasitic potential of plants used in folk medicine in Brazil2025