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September 20, 2025Medicinal Chemistry

In Vitro Evaluation of p-Toluenesulfonyl Hydrazones as Anti-Trypanosoma cruzi and Leishmanicidal Agents

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Authors

EREya Caridad Rodríguez-PupoTDTimoteo Delgado-MaldonadoDNDiana V. Navarrete-Carriola

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Overview

In vitro assessment showed p-toluenesulfonyl hydrazones reduce Trypanosoma cruzi and Leishmania growth, indicating potential new treatments.

Key Points

  • Compound pT-21 demonstrated significant inhibition of T. cruzi proliferation with an IC50 of 49.6 μM.
  • Both pT-15 and pT-21 were effective against L. mexicana, with IC50 values of 59.2 μM and 13.8 μM respectively.
  • Low cytotoxic effects were observed against Vero cell lines with CC50 values exceeding 100 μM.
  • Future research will explore the pharmacological targets of pT-21 to enhance drug design and efficacy.

Cite This Study

Rodríguez-Pupo et al. (2025) studied this question.

synapsesocial.com/papers/68d439fa713b0b5dfea79ce6https://doi.org/10.2174/0115734064390136250818063436
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