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October 3, 2025Current Drug Targets

Cytokeratin 8 as a Novel Therapeutic Target in Type 2 Diabetes Mellitus: Suppression of Hepatic Glycogen Synthesis via IRS1/PI3K/Akt/GSK3β Signaling

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Authors

MSMingzhu SunXLXiuli LiJSJin Sun

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Overview

Functional analysis reveals cytokeratin 8 modulates glycogen synthesis via IRS1/PI3K/Akt/GSK3β signaling in T2DM.

Key Points

  • Cytokeratin 8 (CK8) was identified as a negative regulator of liver glycogen synthesis in type 2 diabetes.
  • CK8 was significantly upregulated while insulin signaling pathways and glycogen synthesis were suppressed.
  • Knockdown of CK8 restored glycogen synthesis, indicating its crucial role in T2DM pathophysiology.
  • Inhibiting CK8 may provide a new therapeutic strategy for enhancing insulin action and glycogen storage.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68e02f3cf0e39f13e7fa24b3https://doi.org/10.2174/0113894501394500250903095958
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Classical and emergent insulin signaling dual changes in type 2 diabetes revealed by human <scp>iPSC</scp>‐derived hepatocytes2025
  2. 2GSK3&amp;#x3B2; serves as a novel therapeutic target in patients with type 2 diabetes mellitus complicated by colorectal cancer2025
  3. 3Elevated ANGPTL8 (Angiopoietin‐Like Protein 8) Levels as a Novel Predictor of Atherosclerosis in Type 2 Diabetes: Beyond Lipid Metabolism2026 · 1 citations
  4. 4Activation of M1 macrophages promotes diabetic kidney disease by modulating glycolysis via HIF-1α-HK2 signaling pathway2025 · 16 citations
  5. 5Targeting hepatocyte-specific SLC2A8 blocks hepatic steatosis and dissociates TCA cycle flux inhibition from glutamine anaplerosis2025