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August 15, 2025Journal of the American Academy of Orthopaedic Surgeons

Evidence for Systemic Perioperative Antibiotic Prophylaxis for Prevention of Fracture-related Infections Following Open Fractures: Systematic Review and Meta-Analysis of Randomized, Controlled, Clinical Trials

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Authors

KKKevin M. KliftoCKChristopher S. KliftoSMSuhail K. Mithani

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Overview

Systematic review assesses systemic antibiotic prophylaxis efficacy for open fractures, suggesting optimal regimens to prevent infections.

Key Points

  • Systemic antibiotic prophylaxis reduces fracture-related infections in open fractures, particularly following Gustilo-Anderson types I through III.
  • A total of 21 randomized controlled trials provided significant insights into the best practices for antibiotic use in these cases.
  • Analysis of clinical guidelines and various study data supports a standard approach to administer antibiotics post-injury.
  • The findings highlight the importance of evidence-based protocols in reducing infection rates stemming from open fractures.

Cite This Study

Klifto et al. (2025) studied this question.

synapsesocial.com/papers/68af7b247567bf4f94ff2fabhttps://doi.org/10.5435/jaaos-d-24-00961
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Meta-Analysis of Acute Systemic Antimicrobial Prophylaxis (ASAP) for Open Extremity Fracture Management: Subgroup Analysis and Methodological Guidelines2025 · 1 citations
  2. 2Paediatric type I open tibia fractures: are antibiotics alone sufficient?2025
  3. 3Comparative effectiveness of prophylactic antibiotic regimens in preventing infection in open fractures: a prospective cohort study2025
  4. 4A Comparison of Piperacillin-Tazobactam With Conventional Antibiotics for Prophylaxis in Lower Extremity Type III Open Fractures2025
  5. 5Are We on the Same Page? Defining Consensus for Pediatric Open Fracture Management Among Level 1 Pediatric Trauma Centers2025