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October 2, 2025Siberian Journal of OncologyOpen Access

Complexities in differential diagnosis of poorly differentiated large cell neuroendocrine carcinoma of the cervix: a case report

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Authors

EME. V. MarkarovaЛГЛ. Е. ГуревичEBE. V. Bondarenko

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Overview

Case report identifies critical diagnostic challenges in neuroendocrine tumors, highlighting treatment complexities.

Key Points

  • The patient exhibited aggressive progression of poorly differentiated large cell neuroendocrine carcinoma.
  • Despite multiple chemotherapy lines and immunohistochemical tests, the patient's condition worsened significantly.
  • Diagnosis of neuroendocrine differentiation is crucial, but often overlooked in these cases.
  • The need for specialized centers to manage neuroendocrine tumors is highlighted by the challenging diagnosis.

Cite This Study

Markarova et al. (2025) studied this question.

synapsesocial.com/papers/68de68e583cbc991d0a20febhttps://doi.org/10.21294/1814-4861-2025-24-4-178-185
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Small Cell Neuroendocrine Carcinoma of the Uterine Cervix: A Case Report Highlighting a Rare and Aggressive Tumor2025
  2. 2Clinical pathological analysis of primary small cell neuroendocrine carcinoma of the cervix: A retrospective study2025 · 1 citations
  3. 3Small cell neuroendocrine carcinoma of the cervix: diagnostic challenges and emerging molecular insights <sup>†</sup>2025
  4. 4Clinical outcomes of neuroendocrine carcinoma of the cervix: Retrospective review from a large academic cancer centre2025
  5. 5Clinicopathologic characteristics and prognostic outcomes of surgically treated neuroendocrine cervical carcinoma: A single institution retrospective analysis2025