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October 1, 2025Hematology ReportsOpen Access

Association of Cognitive Impairment with Reduced Health-Related Quality of Life and Depression Among Survivors of Thrombotic Thrombocytopenic Purpura

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Authors

SSSruthi SelvakumarJYJia YuJMJavier Bolaños Meade

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Overview

Cross-sectional analysis links cognitive impairment with lower health-related quality of life and increased depression in iTTP survivors, suggesting necessary interventions.

Key Points

  • Cognitive impairment is linked to significantly reduced health-related quality of life in iTTP survivors.
  • iTTP survivors had lower mean scores in seven SF-36 domains compared to the reference population.
  • Fluid cognition showed a strong correlation with physical health-related quality of life metrics.
  • Regular mental health screening may help iTTP survivors address depressive symptoms effectively.

Cite This Study

Selvakumar et al. (2025) studied this question.

synapsesocial.com/papers/68dd91c7fe798ba2fc49832bhttps://doi.org/10.3390/hematolrep17050051
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Qualitative Study on Patient Experience with Signs, Symptoms, and Daily Impacts of Immune Thrombocytopenia2025
  2. 2The impact of hereditary TTP on psychological health, cognition, and well-being: a patient-reported outcomes study.2026
  3. 3Progressive Silent Cerebral Infarction is Associated with Stroke and Persistent Cognitive Impairment in iTTP Survivors.2025
  4. 4Mapping White Matter Degeneration in iTTP Survivors: A Diffusion Tensor Imaging Study2025
  5. 5Plasma Interleukin-12 Levels as a Potential Biomarker of Fatigue and Quality of Life in Primary Immune Thrombocytopenia2025