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October 1, 2025Nutrition JournalOpen Access

Clinical randomized trial of vitamin D and C supplementation in critically ill patients with respiratory failure

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Authors

AVAynaz VelayatiMVMohammadreza VafaMYMahdi Yadollahzadeh

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Overview

Randomized trial assessed vitamin D and C's impact on inflammation and clinical outcomes in ICU patients, indicating potential benefits.

Key Points

  • Vitamin D and C supplementation significantly improved inflammation and oxidative status in critically ill patients.
  • At the trial's conclusion, hs-CRP and IL-6 levels decreased significantly in the intervention group (p < 0.001).
  • This double-blind, randomized, placebo-controlled trial included 34 patients in the intervention group and 33 in the control group.
  • Improved inflammation may lead to shorter ICU stays, but supplementation did not significantly affect 90-day mortality rates.

Cite This Study

Velayati et al. (2025) studied this question.

synapsesocial.com/papers/68dd91c7fe798ba2fc49828fhttps://doi.org/10.1186/s12937-025-01214-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vitamin C Supplementation During Intensive Care Unit Stay Is Associated With Improved Outcomes in Critically Ill Patients With Sepsis‐Induced Coagulopathy: A Cohort Study2025
  2. 2Impact of selenium status and supplementation on outcomes in critically ill patients2025
  3. 3Randomized trial of activated vitamin D for acute kidney injury prevention in critically ill patients2025
  4. 4Low vitamin C concentrations and prognosis in critically ill children2025
  5. 5Predictors of Intensive Care Unit Outcomes in Elderly Patients with Acute Respiratory Failure: A Retrospective Cohort Study.2025 · 6 citations