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October 1, 2025Proteoglycan ResearchOpen Access

Decorin Evokes a Pro‐Lysosomal Pathway in Lymphatic Endothelial Cells

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Authors

GPGabriel J. PascalDMDipon Kumar MondalSKSadie Kim

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Overview

Proteomic analysis reveals decorin's role in lysosome pathways in lymphatic cells, highlighting potential cancer targets.

Key Points

  • Decorin triggers pro-lysosomal pathways in lymphatic endothelial cells, enhancing autophagy functions.
  • Notable proteins like Lamp1 and Nedd8 were differentially regulated after decorin treatment, emphasizing their roles.
  • Comprehensive proteomic analysis identified vital protein pathways linked to cancer suppression and lymphangiogenesis.
  • These findings suggest decorin and its regulated proteins could serve as therapeutic targets for cancer treatments.

Cite This Study

Pascal et al. (2025) studied this question.

synapsesocial.com/papers/68dd89e6fe798ba2fc4980c5https://doi.org/10.1002/pgr2.70038
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