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August 15, 2025Journal of Inflammation ResearchOpen Access

Mechanisms of Cancer Cell Lymphatic Endothelialization in Tumor Lymphangiogenesis and Metastasis: A Comprehensive Review

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Authors

JWJingwen WangZHZhandong HuXQXue‐Jiao Qian

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Overview

Comprehensive review explores cancer cell lymphatic endothelialization and its implications for tumor lymphangiogenesis and metastasis.

Key Points

  • Cancer cell lymphatic endothelialization involves transdifferentiation and fusion with endothelial cells, highlighting a unique dual phenotype.
  • Key markers like PDPN and LYVE1 indicate lymphatic endothelialization, with histopathological evidence showing types of lymphangiogenic mimicry.
  • This review provides a theoretical framework that uncovers mechanisms driving metastasis and tumor lymphangiogenesis in cancer progression.
  • Understanding these processes may open new avenues for targeted clinical strategies in treating tumors and their spread.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d64771da7https://doi.org/10.2147/jir.s535351
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