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October 1, 2025Alzheimer s & DementiaOpen Access

Plasma p‐tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic

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Authors

DEDhamidhu EratneMKMatthew KangCMCharles B. Malpas

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Overview

Prospective study assesses plasma biomarkers in Alzheimer's disease and frontotemporal dementia, indicating their utility in distinguishing from psychiatric disorders.

Key Points

  • Plasma p‐tau217 distinguished Alzheimer's disease from frontotemporal dementia with 96% accuracy.
  • NfL effectively differentiated neurodegenerative disorders from psychiatric conditions in the cohort.
  • Blood-based biomarkers offer strong diagnostic potential in complex memory clinic settings.
  • Elevated p‐tau217 in Alzheimer's compared to other disorders underscores its diagnostic relevance.

Cite This Study

Eratne et al. (2025) studied this question.

synapsesocial.com/papers/68dd89defe798ba2fc497d8fhttps://doi.org/10.1002/alz.70717
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma phosphorylated tau-217 correlates with brain atrophy, cognition, and CSF biomarkers in a cognitively healthy community cohort2025 · 7 citations
  2. 2Plasma phosphorylated tau 217 detects amyloid-β in Neuronal Synuclein Disease2025
  3. 3Clinical Validation of Novel Immunoassays for Plasma Phosphorylated Tau 217, 212, 181, 231, and Brain‐Derived Tau Across the Biochemical Spectrum of Alzheimer's Disease2025
  4. 4Combined use of plasma p‐tau217, NfL, and GFAP predicts domain‐specific cognitive decline in cognitively unimpaired and MCI individuals2025
  5. 5Optimizing timing and cost-effective use of plasma biomarkers in Alzheimer’s disease2025