October 8, 2025Brain CommunicationsOpen Access

Plasma phosphorylated tau-217 correlates with brain atrophy, cognition, and CSF biomarkers in a cognitively healthy community cohort

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Observational analysis showed plasma pTau-217 correlates with cognition and brain structure, suggesting its role in Alzheimer's disease.

Higher levels of plasma pTau-217 were linked to lower global cognition scores in dementia-free older adults.
The analysis found that greater plasma pTau-217 levels correlated with decreased cortical thickness, indicating brain atrophy.
Pearson’s correlations revealed a strong connection between plasma pTau-217 and its CSF counterpart among participants with both measurements.
Multiple plasma biomarkers showed significant associations with cognition and neurodegeneration, reinforcing their diagnostic potential.

Sim et al. (2025) studied this question.

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