Effect of Recombinant Human Bone Morphogenic Protein-2 as an Adjunct in Guided Bone Regeneration and in Subjects With Periodontitis- A Systematic Review and Metanalysis

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rhBMP-2 significantly improved bone formation and clinical outcomes in periodontitis patients, enhancing regeneration.
Meta-analysis of seven trials showed improvements in alveolar ridge preservation and reduced defect depth.
Study quality assessment indicated low to moderate risk of bias, enhancing the credibility of the findings.
The findings support rhBMP-2 as a minimally invasive option, yet highlight the need for larger trials for validation.

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Systematic review reveals rhBMP-2 improves bone regeneration outcomes in periodontitis, suggesting its use as an effective adjunct therapy.

Muglikar et al. (2025) studied this question.

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Systematic review reveals rhBMP-2 improves bone regeneration outcomes in periodontitis, suggesting its use as an effective adjunct therapy.