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October 1, 2025Open Access

Risk Factors Associated with Interstitial Lung Disease in Rheumatoid Arthritis: A Monocentric Clinical and Serological Assessment

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Authors

NLNing LiuYZYongfeng ZhangGWGang Wang

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Overview

Analysis identifies risk factors and develops a predictive model for interstitial lung disease in rheumatoid arthritis patients, highlighting key biomarkers.

Key Points

  • Risk factors include male gender, smoking, and elevated biomarkers, with significant associations found.
  • Optimal biomarker thresholds were established: rheumatoid factor > 352.5 IU/mL and anti-CCP antibodies > 43.25 IU/mL.
  • Multivariate analysis confirmed C3, TNF-α, and biologic therapy as independent predictors for interstitial lung disease.
  • The nomogram demonstrated strong discrimination with a C-index of 0.829, facilitating early risk stratification.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68dd89d7fe798ba2fc497afdhttps://doi.org/10.21203/rs.3.rs-7500736/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comprehensive analysis of patients with rheumatoid arthritis associated interstitial lung disease2025 · 2 citations
  2. 2Are we screening effectively? A systematic review and meta-analysis of proposed risk factors for rheumatoid arthritis-associated interstitial lung disease screening2025
  3. 3Screening for rheumatoid arthritis-associated interstitial lung disease: Current evidence and next steps needed for routine clinical use2025 · 4 citations
  4. 4Profile of Patients with Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Single-Center2025
  5. 5Screening for Rheumatoid Arthritis-Associated Interstitial Lung Disease Using Low-Dose CT: An Emerging Approach — An Observational Prospective Case-Control Study2025