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September 25, 2025Open Access

Correlation Between Periodontitis and Non-Alcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis

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Authors

HLHong LiMSMingxuan ShiYRYuan Ren

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Overview

Systematic review shows a significant link between periodontitis and NAFLD, indicating a need for further studies.

Key Points

  • A significant association between periodontitis and NAFLD was established, with an odds ratio of 1.24.
  • The analysis included 12 studies, highlighting a stronger link with periodontitis diagnosed by clinical attachment loss.
  • Heterogeneity was lower among cross-sectional studies, suggesting more robust findings in that group.
  • Cohort studies indicate a bidirectional relationship, yet more high-quality research is necessary to confirm these findings.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d5e205bd7882ccb9b86ab4https://doi.org/10.21203/rs.3.rs-7434817/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Non-alcoholic fatty liver disease and periodontitis – clinical and pathogenetic relationships2025
  2. 2Is Obesity a Risk Factor for Periodontitis? A Systematic Review and Meta‐Analysis2025
  3. 3Is Periodontal Inflammation Associated with Liver Cirrhosis? A Cross-Sectional Study2025
  4. 4Proteomics reveals periodontitis-driven oxidative stress and lipid metabolism disruption in NAFLD2025
  5. 5Association between air pollution and risk of non-alcoholic fatty liver disease: an updated meta-analysis2025