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September 5, 2025Frontiers in EndocrinologyOpen Access

Proteomics reveals periodontitis-driven oxidative stress and lipid metabolism disruption in NAFLD

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Authors

BSBoyuan SunXLXiaomeng LiuYJYixuan Jiang

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Implication

Proteomics revealed that periodontitis accelerates oxidative stress and lipid metabolism disruption in NAFLD progression.

Key Points

  • Periodontitis exacerbates hepatic lipid accumulation and oxidative stress, contributing to NAFLD progression.
  • Proteomic analysis identified 244 differentially expressed proteins linked to metabolic pathways and inflammation.
  • Protein-protein interaction network highlighted ACOX1, DBT, ACAA2, and HADHA as important hub proteins.
  • Downregulation of these hub proteins shows a connection to lipid oxidation impairment and liver injury.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68c23887b210217d6477800ehttps://doi.org/10.3389/fendo.2025.1600015
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