September 25, 2025Open Access

Multi-omic screening identifies RBMXL3 as a primate-specific RNA-binding protein and candidate regulator of RNA metabolism in human spermatogenesis

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Analysis uncovers the role of rbmxl3 in RNA metabolism and retrotransposition in germ cells, suggesting its significance in spermatogenesis.

RBMXL3 impacts rna metabolism, highlighting its role in sperm development and potentially in cancer.
The study utilized transcriptomic and proteomic approaches, leveraging the human seminoma cell line for insights.
RBMXL3 specifically restricts human line-1 retrotransposition, underscoring its molecular function in germline cells.
Findings indicate rbmxl3's contribution to transcriptome regulation in male germ cells, warranting further exploration.

Barszcz et al. (2025) studied this question.

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Analysis uncovers the role of rbmxl3 in RNA metabolism and retrotransposition in germ cells, suggesting its significance in spermatogenesis.