Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
October 9, 2025Circulation Research

Abstract NBT102: RBX1 Is an Indispensable, Dosage-Sensitive Regulator of Perinatal Heart Development

View Full Paper
Ask AI
Bookmark
Share

Authors

JZJosué Zambrano-CarrascoKJKai JiaoJLJie Li

Discussion

Loading...

Member takes

Overview

This study demonstrates rBX1's crucial role in cardiac development, showing its dosage sensitivity in congenital heart disease.

Key Points

  • RBX1 is essential for proper cardiac development and its deficiency leads to perinatal lethality.
  • Deletion of a single Rbx1 allele in mice caused myocardial hypoplasia and ventricular septal defects.
  • RBX1 regulates cardiomyocyte proliferation and maturation through the Hippo-YAP pathway.
  • Transcriptomic analysis revealed disruptions in essential transcriptional networks for cardiogenesis in RBX1-deficient hearts.

Cite This Study

Zambrano-Carrasco et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fb0bhttps://doi.org/10.1161/res.137.suppl_1.nbt102
View Full Paper
Ask AI
Bookmark
Share