September 25, 2025Open Access

Antidiarrheal activity assessment of Operculina turpethum stem extract and in silico analysis of its compounds

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Animal model shows significant antidiarrheal effects of Operculina turpethum stem extract, highlighting compounds with potential mechanisms.

The ethanolic extract of O. turpethum at 250 and 500 mg/kg significantly reduces diarrhea in mice, indicating effective antidiarrheal properties.
Molecular docking revealed that three compounds from O. turpethum exhibit binding affinities comparable to loperamide against M3 muscarinic acetylcholine receptors.
The study utilized a castor oil-induced mouse model to validate the antidiarrheal effects of the stem extract and its compounds.
These results support further exploration of O. turpethum for potential therapeutic applications in diarrhea management.

Fahad et al. (2025) studied this question.

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Animal model shows significant antidiarrheal effects of Operculina turpethum stem extract, highlighting compounds with potential mechanisms.