Antidiarrhea Activity of Ethyl Acetate Fraction of Ocimum gratissimum in Castor Oil-induced Diarrhea in Rats

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Experimental analysis shows that ethyl acetate fraction reduces diarrhea in rats, indicating potential therapeutic benefits of Ocimum gratissimum.

The ethyl acetate fraction significantly reduced diarrhea in Wistar rats and demonstrated a dose-dependent effect.
Percent inhibition of diarrhea increased with higher doses (200, 400, and 800 mg/kg) compared to the negative control group.
Assessment involved castor oil-induced diarrhea models and other tests, confirming the antidiarrheal properties.
Results suggest that phytochemicals in Ocimum gratissimum contribute to its antidiarrheal efficacy.

Ezeigwe et al. (2025) studied this question.

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Experimental analysis shows that ethyl acetate fraction reduces diarrhea in rats, indicating potential therapeutic benefits of Ocimum gratissimum.