History and Evolution of Innovations in Clinical Pharmacology

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This review traces innovations in clinical pharmacology, highlighting drug development improvements and regulatory science implications.

Gradual shifts toward quantitative modeling have enhanced drug development efficiency and safety assessments.
Improvements in data from preclinical studies have facilitated translational insights into human clinical trials.
The interplay between the pharmaceutical industry and regulatory agencies shapes future innovations in therapy evaluation.
Understanding drug–drug interactions is crucial for optimized dose selection and risk-benefit analysis.

Lesko et al. (2025) studied this question.

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