September 10, 2025

Advancements in Clinical Trial Methodologies: A Century in Review

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This review analyzes advancements in clinical trials, highlighting adaptive designs and big data integration.

Clinical trials have evolved significantly, showcasing a shift from static to complex, adaptive methodologies.
Key methodologies include randomized controlled trials, adaptive designs, and modern innovations that improve trial efficiency.
Recent challenges and innovations, such as artificial intelligence and decentralized trials, are transforming clinical research.
The review emphasizes that these advancements improve accessibility and streamline processes in clinical trials.

Haoxuan Sun (2025) studied this question.

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