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September 25, 2025Cancer Immunology Research

Abstract A002: Comprehensive blood profiling for immunotherapy outcome prediction and longitudinal immune trajectory characterisation

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Authors

MEMax EmmerichDMDuncan R. McKenzieCCCarla Castignani

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Overview

High-throughput spectral cytometry identifies patient response and irAE development, suggesting targeted interventions.

Key Points

  • Benefit prediction for immunotherapy achieved AUCs of 0.814 and 0.85 at baseline and C2, respectively.
  • Severe immune-related adverse event (irAE) prediction scored AUCs of 0.84 and 0.82 for baseline and C2 evaluations.
  • Analysis utilized 706 cryopreserved PBMC samples through high-content profiling and machine learning techniques.
  • Findings reveal significant immune signatures associated with treatment response and adverse event severity.

Cite This Study

Emmerich et al. (2025) studied this question.

synapsesocial.com/papers/68d5dabfddad3c16d4636fa2https://doi.org/10.1158/2326-6074.cimm25-a002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract A001: nELISA high-throughput protein profiling applied to the RADIOHEAD cohort: insights from the largest plasma proteomics study of patients receiving checkpoint inhibitor therapy2025
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  3. 3Circulating CD161high CD8 T cells at leukapheresis are associated with reduced risk of progression at 12 months (PFS12) in large B-cell lymphoma treated by axicabtagene ciloleucel: Results from the Phase 2 alycante study (LYSA)2025
  4. 4Innate and adaptive immune features associated with immune-related adverse events2025 · 14 citations
  5. 5Abstract B001: Leveraging peripheral leukocyte recruitment to improve efficacy and mitigate toxicities following checkpoint blockade2025