Innate and adaptive immune features associated with immune-related adverse events

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Discussion

Analysis identifies immune-related adverse events in cancer treatment, suggesting immune biomarkers for prediction.

Patients with immune-related adverse events developed a significant proinflammatory state, enhancing clinical outcomes.
Baseline levels of CD57 + T and NK T cells, and elevated ANA were significantly higher in patients with adverse immune events.
Single-cell RNA sequencing and mass cytometry highlighted critical gene signatures in monocytes and T/NK cells associated with irAE development.
The findings reveal potential biomarkers for predicting immune-related adverse events caused by immune checkpoint inhibitors.

Khan et al. (2025) studied this question.

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