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September 25, 2025Stem Cell Reviews and ReportsOpen Access

Investigating the Therapeutic Efficacy of Quality-Controlled, miR-146a-5p-Enriched Small Extracellular Vesicles Derived From MSCs Against Idiopathic Pulmonary Fibrosis

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Authors

XWXin WangLMLingjiao MengQWQiuhong Wang

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Overview

Research demonstrates anti-inflammatory effects of small extracellular vesicles in idiopathic pulmonary fibrosis, suggesting miR-146a-5p is a key therapeutic target.

Key Points

  • UC-sEvs significantly inhibit inflammatory responses in idiopathic pulmonary fibrosis by regulating macrophage function.
  • The therapeutic cargo was confirmed through RNA-seq analysis, revealing crucial miRNA profiles and effects.
  • A GMP-grade process was established for isolating UC-sEvs, ensuring quality standards and product stability.
  • miR-146a-5p was identified as pivotal in decreasing IPF progression by targeting TRAF6/IRAK1 to manage inflammation.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d5d0d7ddad3c16d4635c03https://doi.org/10.1007/s12015-025-10976-8
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Also Consider

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  1. 1MicroRNA-4516 in extracellular vesicles-derived mesenchymal stem cells suppressed integrin αV-mediated lung fibrosis2025 · 4 citations
  2. 2Engineered Mesenchymal Stem Cells-derived Small Extracellular Vesicles Mitigate Liver Fibrosis by Delivering USP10 to Reprogram Macrophage Phenotype.2025 · 6 citations
  3. 3Regenerative restoration of chronic obstructive pulmonary disease by human umbilical cord blood small extracellular vesicles2025
  4. 4Bone Marrow Mesenchymal Stem Cell-Derived Exosomes microRNA-31-5p Repress Pulmonary Fibrosis via IGFBP7.2025 · 3 citations
  5. 5Preliminary exploration of the ability of HUC-MSCs to restore the lung microbiota and related metabolite disorders in IPF treatment: combining 16S sequencing and metabolite analysis2025 · 3 citations