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August 15, 2025Stem Cell Research & TherapyOpen Access

MicroRNA-4516 in extracellular vesicles-derived mesenchymal stem cells suppressed integrin αV-mediated lung fibrosis

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Authors

ISIssei SumiyoshiJuntendo UniversitySTShinsaku TogoJuntendo UniversityJWJunko WatanabeJikei University School of Medicine

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Implication

Study demonstrates MSC-derived extracellular vesicles inhibit lung fibrosis in a mouse model, suggesting potential for treating IPF.

Key Points

  • Administration of MSC-derived extracellular vesicles significantly reduced TGF-β1-induced lung fibrosis outcomes.
  • Treatment decreased collagen gel contraction and migration in fibroblasts, highlighting antifibrotic properties.
  • Analysis of mice revealed that miR-4516 mediates the effects of extracellular vesicles on lung fibrosis.
  • Findings indicate that MSC-derived extracellular vesicles present a new therapeutic strategy against pulmonary fibrosis.

Cite This Study

Sumiyoshi et al. (2025) studied this question.

synapsesocial.com/papers/68af2d6fcf1dd9ea359e4f81https://doi.org/10.1186/s13287-025-04559-0
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